Abstract Search

Pluripotent mesenchymal stem cells (MSCs) have the capacity to differentiate into osteoblasts, adipocytes and chondrocytes and are characterised by expression of CD105, CD90 and CD73. CD73 is the enzyme that dephosphorylates AMP to adenosine. The role of adenosine in MSCs is unknown and we have thus investigated whether it plays a role in the differentiation process to osteoblasts.MSCs, obtained from the bone marrow of 10 week old male rats, were expande...

0 shares

ea0013p165 | Diabetes, metabolism and cardiovascular | SFEBES2007

Bone marrow stem cells differentiating along the adipogenic lineage show marked up regulation of the adenosine A1 receptor transcript

Easter Tammy , Lewis B Mary , Elford Carole , Ludgate Marian , Ham Jack , Evans Bronwen , Scanlon Maurice , Lewis Mark

Bone marrow stem cells (BMSCs) are able to differentiate along multiple lineages including adipogenic and osteogenic lineages. The adenosine A1 receptor (A1R) modulates adipose tissue function causing an inhibition of lipolysis. We therefore studied A1R expression in BMSCs induced to differentiate along the adipogenic lineage.BMSCs were isolated from rat femur (10 wk male Wistar), cultured in control medium (alphaMEM 10% FCS) and then plated into adipocy...

0 shares

Endocrine Abstracts

Adenosine is an important regulator of mesenchymal stem cell differentiation into osteoblasts

Bone marrow stem cells differentiating along the adipogenic lineage show marked up regulation of the adenosine A1 receptor transcript

BiosciAbstracts